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Aspi­rin (ASA) and throm­bo­sis du­ring hip and knee surgery

What you should know:

If you are plan­ning a hip or knee re­pla­ce­ment, soo­ner or la­ter you will hear the word throm­bo­sis. And the same ques­tion al­most al­ways arises: 

What role does aspi­rin (ASA) play be­fore and af­ter the operation?

In fact, there are two dif­fe­rent si­tua­tions that should be cle­arly distinguished:

  1. Many peo­ple al­re­ady take ASA be­cause of he­art or vas­cu­lar diseases.
  2. In cer­tain ca­ses, ASA is also used spe­ci­fi­cally as a throm­bo­sis pro­phy­la­xis af­ter an ope­ra­tion.

This di­stinc­tion is cru­cial be­cause the re­com­men­da­ti­ons dif­fer si­gni­fi­cantly in each case.


ASS be­fore a hip/knee ope­ra­tion: Please do not ch­ange any­thing yourself

If you are al­re­ady ta­king ASA, the fol­lo­wing ap­plies:
Never stop ta­king the me­di­ca­tion on your own.

ASA is of­ten pre­scri­bed for he­art pro­blems or af­ter a stent. In these ca­ses, un­con­trol­led dis­con­ti­nua­tion can be dangerous. 

At the same time, ASA in­crea­ses the risk of blee­ding du­ring the ope­ra­tion – this is why it is al­ways de­ci­ded on an in­di­vi­dual ba­sis whe­ther you should con­ti­nue to take ASA, pause it or tem­po­r­a­rily ch­ange it.

We will dis­cuss your cur­rent me­di­ca­tion carefully in our sur­gery and then de­cide which pro­ce­dure is best sui­ted to your case.

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ASA af­ter sur­gery: is it en­ough to pro­tect against thrombosis?

Af­ter a hip or knee re­pla­ce­ment, there is an in­creased risk of throm­bo­sis for a few weeks. In cer­tain ca­ses, ASA can be a sui­ta­ble op­tion – but not for ever­yone.

  • In pa­ti­ents wi­t­hout ad­di­tio­nal risk (e.g. wi­t­hout pre­vious throm­bo­sis or tu­mour di­se­ase), ASA may be suf­fi­ci­ent and a fast-track or ra­pid re­co­very con­cept with early mo­bi­liza­tion may be used.
  • Ho­we­ver, if there are other risk fac­tors, a stron­ger blood thin­ner is usually ne­ces­sary.
    Im­portant: Your doc­tor will al­ways de­cide which me­di­ca­tion is right for you – de­pen­ding on your si­tua­tion, mo­bi­lity and pos­si­ble con­co­mi­tant illnesses.

What else counts: Mo­ve­ment and balance

Throm­bo­sis pro­phy­la­xis me­ans more than just me­di­ca­tion.
A key point is early exer­cise: The soo­ner you be­come ac­tive again af­ter the ope­ra­tion, the lower your risk.

It is also im­portant to strike a good ba­lance between

  • ade­quate pro­tec­tion against thrombosis
  • and the lo­west pos­si­ble risk of bleeding.

So­me­ti­mes ASA is en­ough – so­me­ti­mes he­pa­rin or other mo­dern ac­tive in­gre­di­ents are nee­ded. The de­cisive fac­tor is al­ways your per­so­nal risk. 


This is how throm­bo­sis pro­phy­la­xis works over time du­ring a hip or knee operation:
  • Be­fore the ope­ra­tion: All me­di­ca­tion is che­cked and ad­jus­ted if necessary.
  • Af­ter the ope­ra­tion: mo­bi­lize early, start throm­bo­sis prophylaxis.
  • In the first few days: exer­cise re­gu­larly and take your me­di­ca­tion consistently.
  • Af­ter a knee ope­ra­tion or knee pro­sthe­sis: usually about 2 weeks of pro­tec­tion required.
  • Af­ter a hip ope­ra­tion or hip pro­sthe­sis: Usually 4–5 weeks.

Ty­pi­cal mi­sun­derstan­dings about ASD
  • “ASA is more harm­less than other blood thin­ners” – not true. ASA is ef­fec­tive, but only in the right situation.
  • “ASA is al­ways the same as ASA” – also wrong.
    It makes a big dif­fe­rence whe­ther you take ASA be­fore the ope­ra­tion as a per­ma­nent me­di­ca­tion or af­terthe ope­ra­tion for throm­bo­sis prophylaxis.

Ex­pe­ri­ence makes the difference

With a hip or knee pro­sthe­sis in par­ti­cu­lar, the suc­cess of the tre­at­ment de­pends not only on the ope­ra­tion its­elf, but also on good plan­ning be­fore and af­ter.

Wahlarztordination 18. Bezirk Wien ► Dr. Maximilian Kasparek

Dr. Ma­xi­mi­lian Kas­pa­rek spe­cia­li­zes in hip and knee pro­s­the­ses and at­ta­ches great im­portance to in­di­vi­du­ally tail­o­red throm­bo­sis prophylaxis.

His ap­proach:

  • Tho­rough ana­ly­sis of your per­so­nal risk
  • Pre­cise coor­di­na­tion of all medications
  • Struc­tu­red and safe fol­low-up treatment

Espe­ci­ally when it co­mes to ASD, ex­pe­ri­ence and careful con­side­ra­tion count.


Con­clu­sion: ASA can be useful – but not always

ASA now plays an im­portant role in throm­bo­sis pro­phy­la­xis af­ter joint re­pla­ce­ment.
But it is not a stan­dard so­lu­tion for ever­yone. The de­cisive fac­tors are your in­di­vi­dual risk, the type of ope­ra­tion and the over­all treatment.


Fre­quently as­ked ques­ti­ons (FAQ)

Why is the risk of throm­bo­sis in­creased af­ter hip re­pla­ce­ment or knee re­pla­ce­ment?

Af­ter hip or knee joint sur­gery, the body has a tem­po­rary “alarm re­ac­tion”: the blood co­agu­la­tes more ea­sily to stop blee­ding and at the same time pa­ti­ents are in­iti­ally less mo­bile. This com­bi­na­tion of sur­gery, re­du­ced mo­ve­ment and al­te­red co­agu­la­tion in­crea­ses the risk of throm­bo­sis in the leg veins, espe­ci­ally in the first few weeks af­ter the operation. 

What role does ASA (aspi­rin) play af­ter a hip or knee re­pla­ce­ment?

ASA can be used af­ter a hip or knee re­pla­ce­ment in sel­ec­ted pa­ti­ents as a blood thin­ner to pre­vent throm­bo­sis.
Ho­we­ver, the cur­rent gui­de­lines only per­mit ASA if there is no in­creased risk of throm­bo­sis and a mo­dern tre­at­ment con­cept with very early mo­bi­liza­tion is implemented.

Is ASA stan­dard for throm­bo­sis pro­phy­la­xis af­ter hip or knee re­pla­ce­ment?

ASA is not a stan­dard so­lu­tion for ever­yone, but an ad­di­tio­nal op­tion.
For many pa­ti­ents – espe­ci­ally those at hig­her risk – other blood thin­ners such as he­pa­rin or mo­dern ta­blets (NOACs) con­ti­nue to be used be­cause they can of­fer grea­ter protection.

Can ASA com­ple­tely re­place he­pa­rin in­jec­tions?

In cer­tain si­tua­tions, ASA can re­place he­pa­rin in­jec­tions, espe­ci­ally in pa­ti­ents wi­t­hout ad­di­tio­nal risk fac­tors and with good early mo­bi­liza­tion.
Ho­we­ver, he­pa­rin or an­o­ther strong blood thin­ner is of­ten still re­com­men­ded for hig­her-risk patients.

How long do I need blood thin­ners af­ter a hip or knee re­pla­ce­ment?

Af­ter a hip pro­sthe­sis, throm­bo­sis pro­phy­la­xis is usually re­com­men­ded for around 4–5 weeks be­cause the risk of throm­bo­sis re­mains in­creased du­ring this pe­riod.
Af­ter a knee pro­sthe­sis, the du­ra­tion is usually so­me­what shorter and is of­ten around 2–3 weeks; ho­we­ver, it is al­ways ad­jus­ted in­di­vi­du­ally ac­cor­ding to the course of the ope­ra­tion, mo­bi­lity and per­so­nal risk.

ASA is of­ten per­cei­ved as “ea­sier” be­cause many peo­ple are fa­mi­liar with it from ever­y­day life, for ex­am­ple as a hea­da­che ta­blet.
Ho­we­ver, ASA – like other blood thin­ners – can ac­tually pro­mote blee­ding and should only be used if it makes me­di­cal sense.

What is the dif­fe­rence bet­ween ASA as a long-term me­di­ca­tion and ASA as throm­bo­sis pro­phy­la­xis?

ASA as a long-term me­di­ca­tion is mainly used for car­dio­vas­cu­lar di­se­a­ses such as he­art at­tacks or stent im­plan­ta­tion to pre­vent blood clots in co­ro­nary ves­sels.
ASA as throm­bo­sis pro­phy­la­xis af­ter hip or knee re­pla­ce­ment, on the other hand, is used to pre­vent blood clots in the leg veins and is li­mi­ted in time – the ob­jec­ti­ves and frame­work con­di­ti­ons dif­fer significantly.

Why am I not al­lo­wed to stop ASA mys­elf be­fore the ope­ra­tion?

If ASA has been pre­scri­bed for he­art or vas­cu­lar di­se­a­ses, it pro­tects against dan­ge­rous vas­cu­lar oc­clu­si­ons, for ex­am­ple in the he­art or brain. Dis­con­ti­nuing it wi­t­hout aut­ho­riza­tion can sud­denly re­move this pro­tec­tive shield and in­crease the risk of he­art at­tack or stroke; the­r­e­fore, a doc­tor must al­ways de­cide whe­ther and when it is sen­si­ble and safe to take a break. 

Is exer­cise alone en­ough to pre­vent throm­bo­sis af­ter hip or knee re­pla­ce­ment?

Early mo­bi­liza­tion and re­gu­lar exer­cise are a key com­po­nent in re­du­cing the risk of throm­bo­sis af­ter hip or knee re­pla­ce­ment.
Nevert­hel­ess, they do not re­place drug-ba­sed throm­bo­sis pro­phy­la­xis for most pa­ti­ents, but ra­ther sup­ple­ment it – both tog­e­ther of­fer si­gni­fi­cantly bet­ter protection.

How is it de­ci­ded whe­ther I should be gi­ven ASA or an­o­ther blood thin­ner?

The de­cis­ion de­pends on se­ve­ral fac­tors: Type of sur­gery (hip re­pla­ce­ment or knee re­pla­ce­ment), your in­di­vi­dual risk of throm­bo­sis, any pre-exis­ting con­di­ti­ons, pre­vious throm­bo­ses and your risk of blee­ding. Du­ring your tre­at­ment, these points will be as­ses­sed in de­tail and on this ba­sis the doc­tor will de­cide whe­ther ASA is suf­fi­ci­ent or whe­ther a stron­ger blood thin­ner such as he­pa­rin or a NOAC is more appropriate. 


Well pre­pared for your knee and hip surgery

Are you ta­king ASA or would you like to know which throm­bo­sis pro­phy­la­xis is right for you? I will dis­cuss your per­so­nal si­tua­tion with you in my sur­gery in Vi­enna and work with you to de­ve­lop the right tre­at­ment plan. 
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Priv.Doz. DDr.
Maximilian Kasparek, MSc

haelsi Gesundheitszentrum im Achtzehnten Theresiengasse 46/2 1180 Vienna

+43 1 399 08 63
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